Gene

tnpo2a

ID

ZDB-GENE-040822-16

Name

transportin 2a

Symbol

tnpo2a Nomenclature History

Previous Names

tnpo2
fb01c02
fe01f03
ik:tdsubc_2a7
tdsubc_2a7
wu:fb01c02 (1)
wu:fe01f03 (1)
wu:fe16e12 (1)
xx:tdsubc_2a7
zgc:101009

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within intracellular protein transport. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to human TNPO2 (transportin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148634 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnpo2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies	Alliance	Intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies	619556

Associated With tnpo2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001494	Importin-beta, N-terminal domain
Family	IPR040122	Importin beta family
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR000357	HEAT repeat